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KMID : 1123820060080020085
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Health & sports medicine
2006 Volume.8 No. 2 p.85 ~ p.92
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Exercise and lactate shuttle
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Jin Jung-Kwon
Le Dae-Taek
Lee Myung-Chun
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Abstract
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This paper examines the process of lactate production and uptake in skeletal muscle. Muscle has been viewed primarily as a producer of lactate which related to oxygen deficit and fatigue, but is now considered to be a major site of lactate uptake. Skeletal muscle has a large capacity for lactate oxidation and it is enhanced by exercise. Lactate exchanges are facilitated by membrane-bound MCT. Lactate dehydrogenase (LDH) controls the formation of lactate and may regulate the turnover of lac-tate in the muscle cell. Skeletal muscle contains five LDH isoforms (LDH 1-5). Endurance training decreases muscle lactate con-centrations by increasing lactate clearance and by decreasing lactate production.
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KEYWORD
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Lactate, LDH, MCT, fatigue, energy metabolism
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